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Dr. Aileen Lynch
Assistant Professor, School of Nursing & Midwifery
Assistant Professor, Trinity Inst. of Neurosciences (TCIN)

Biography

Dr. Aileen Lynch graduated with a BSc in Biochemistry (1995) from NUI, Cork. She then pursued a postgraduate degree in Neuroscience and graduated with an MSc in Neuroscience (1996) from King's College, London. She carried out a project which investigated the effect of excitatory amino acids on the phosphorylation state of the microtubule-associated protein tau as part of the MSc course. In 2000, Dr. Lynch graduated with a PhD in Neuroanatomy from Imperial College, London. Her PhD involved the study of dendritic spines and glutamatergic cells in schizophrenic post-mortem tissue. Dr. Lynch began her postdoctoral research in the Department of Physiology and the Institute of Neuroscience, Trinity College in 2000 where she investigated the signalling mechanisms which induce cellular damage in the aged brain. In 2002 she was awarded a HRB Postdoctoral Research Fellowship which investigated the age-related deterioration in synaptic function in rat hippocampus. Continuing with the theme of neuroinflammation, in 2005 Dr. Lynch began a SFI Postdoctoral Research Fellowship which investigated if the aged brain is more vulnerable to additional inflammatory insult. In 2007, Dr. Lynch was appointed a lectureship in the School of Nursing and Midwifery and is continuing to research strategies that modulate the inflammatory processes that occur during the ageing process.

Publications and Further Research Outputs

Peer-Reviewed Publications

Sheerin, Fintan Lynch, Aileen Kilroy, Sean Epstein, Monique Girault, Ariane Larose, Inès Gillois, Pierre Rolland, Carole McKinney, Ciarán Harkin, Mary McKee, Gabrielle, A Qualitative Study Exploring Facilitators and Barriers to Engagement in Physical Activity Among Older Irish and French Adults, Age and Ageing , Irish Gerontological Society 67th Annual and Scientific meeting , Clayton Hotel Silver Springs, Cork, 26-28 September 2019, 48, (Supplement 3), Oxford Academic, 2019, ppiii17 - -iii6 Poster, 2019 DOI URL

Sean Kilroy , Gabrielle McKee, Aileen Lynch, The impact of Physical Activity on Cardiovascular Disease and Cardiometabolic Risk Factors in CommunityDwelling Older Adults: Results for The Irish Longitudinal Study on Ageing (TILDA) , Prevention Matters: Making the Difference. 5th Annual National Prevention Conference, Johnstown Estate hotel , Enfield, Ireland , 23rd Nov, 2018 Poster, 2018

Sean Kilroy, Gabrielle McKee, Aileen Lynch, Role of Cardio-metabolic Risk Factors in the Relationship Between Physical Activity and Cardiovascular Disease: the Irish Longitudinal Study on Ageing TILDA , Age and Aging , the Irish Gerontological Society Transforming Ageing Across Borders , Slieve Russell Hotel, Ballyconnell, Co. Cavan, 27-29 Sept 2018, 5, (Supp 5), Oxford Academic, 2018, pp1-12 Meeting Abstract, 2018 URL DOI

S Kilroy, G McKee, A Lynch , The impact of physical activity on cardiovascular disease and cardio-metabolic risk factors in community dwelling older adults: results from the Irish Longitudinal Study on Ageing, European Journal of Preventive Cardiology, Europrevent 2018, Ljubljana , 19th - 21st April, 25, (Supp 1), 2018, pp6 (23) Meeting Abstract, 2018 DOI URL

Nicholl, H., Tracey, C., Begley T., King C., Lynch A.M., Parents of Children with Rare Conditions Internet Use - Findings from a Study on Parents Web Information Needs., Journal of Medical Internet Research, 19, (2), 2017, p51 - 65 Journal Article, 2017

Dr Honor Nicholl, Ms Carmel Doyle, Ms Jessica Eustace-Cook, Ms Geraldine Prizeman, Dr Catherine Tracey, Dr Aileen Lynch, Ms Clair Kelly, Exploring the challenges experienced by people with muscular dystrophy living independently (MD INDOLIVING), School of Nursing and Midwifery, University of Dublin Trinity College, University of Dublin Trinity College, 2016, 1-75 Report, 2016 URL TARA - Full Text

Nicholl, H., Doyle, C., Eustace-Cook, J., Kelly, C., Prizeman, G., Tracey, C., Lynch, A.M., Exploring the challenges experienced by people with muscular dystrophy living independently, The European Conference on Rare Diseases & Orphan Products, Edinburgh, UK, 26-28 May 2016, 2016, ppP 95 Poster, 2016

Nicholl, H., Eustace-Cook, J., King, C., Murphy, M., Prizeman, G., Tracey, C., Lynch, A.M., Rare Diseases Website: Developing the Parent-to-Parent Content of a Rare Disease Website in Ireland. , Palliative Medicine, European Association of Palliative Care, Dublin, Ireland, 30, (6), SAGE, 2016, pp50 - 50 Conference Paper, 2016

Lynch A., Nicholl H., Tracey C. , Sharing experiences of conducting focus groups with populations across the healthcare spectrum. , International Journal of Qualitative Methods , Qualitative Methods Conference, Glasgow, UK, 15, (1), SAGE, 2016, pp1 - 10 Conference Paper, 2016

Nicholl H, Eustace-Cook J, King C, Lynch A, Murphy M, Tracey C , Liam's Lodge: A National Children's Care Centre for Children with Rare, Genetic and Life Limiting Conditions and A Children's Palliative Care Respite Service for Munster and the Mid-West. , June , 2015, p1 - 64 Report, 2015

Nicholl N, Lynch A, Begley T, King C, Tracey C, Perspectives of parents informing the development of the first i rish web resource on children with rare conditions - implications for practice., 34th Annual International Nursing & Midwifery Research & Education Conference 2015, 19th February 2015, 2015, pp101- Meeting Abstract, 2015 URL

Nicholl H., Eustace-Cook J., King C., Murphy M., Prizeman G., Tracey C & Lynch A., Rare diseases website - Developing the Parent-to-Parent Content of a Rare Disease Website in Ireland, SON&M TCD, University of Dublin Trinity College, September , 2015, p1 - 70 Report, 2015 TARA - Full Text

Honor Nicholl, Jessica Eustace-Cook, Carole King, Maryanne Murphy Ms Geraldine Prizeman, Catherine Tracey, Aileen Lynch, Rare diseases website developing the parent - to - parent content of a rare disease website in Ireland, School of Nursing and Midwifery , University of Dublin Trinity College, September, 2015 Report, 2015 URL

King C., Nicholl H., Tracey C., Lynch A. & Begley T. , Parents of children and young People with Rare diseases and their Information Needs : Does the Internet Help?, 5th Annual Nursing & Research conference , The Children's University Hospital Temple St, 5th March , 2015, pp8- Meeting Abstract, 2015

Dr Honor Nicholl, Ms Thelma Begley, Ms Carole King, Dr Aileen Lynch, Dr Catherine Tracey, Rare Diseases Web-Information For Families in Ireland (RD-WIFI), online, Trinity College Dublin, September, 2014, p1- Report, 2014 TARA - Full Text

Sean Kilroy, Aileen Lynch, Gabrielle Mckee, The relationship between cardiac health and physical activity levels in older adults , Irish Journal of Medical Science, 62nd Annual and Scientific Meeting of the Irish Gerontological Society, Galway, 9-11October, 183, (Supp 7), Springer , 2014, ppS349- Published Abstract, 2014 URL

Lorraine M. Murray, Christoph W. Blau, Anthony Lyons, Marina A. Lynch, Aileen M. Lynch, Increased blood-brain barrier permeability in ex vivo brain from aged Wistar rats - the role of IL-1 mediated tight junction disruption, Irish Journal of Medical Science, Neuroscience Ireland Meeting 2011, September 2011, 180, 2011 Meeting Abstract, 2011

Lorraine M. Murray, Christoph W. Blau, Anthony Lyons, Marina A. Lynch, Aileen M. Lynch, Modulation of blood-brain barrier permeability and decreased claudin-5 expression from aged Wistar rats - a role for IL-1?, Irish Journal of Medical Science, RAMI Section of Biomedical Sciences Annual Meeting, 180, 2011 Meeting Abstract, 2011

L. M. Murray, C. W. Blau, M. A. Lynch, A. M. Lynch, Regional modulation of blood-brain barrier permeability and decreased claudin-5 expression in ex vivo brain from aged Wistar rats, Irish Journal of Medical Science, RAMI Section of Biomedical Sciences Annual Meeting, September 2010, 180 (Suppl 2), 2011, ppS15 - S65 Meeting Abstract, 2011

The Reproductive System in, editor(s)Imelda Coyne, Freda Neill, and Fiona Timmins , Clinical Skills in Children's Nursing , UK, Oxford University Press, 2010, [Chenery-Morris, S. & Lynch, A.M.] Book Chapter, 2010

Higgins, A., Nash, M. & Lynch, A.M., Antidepressants-associated sexual dysfunction: impact, effects and treatment, Drug, Healthcare and Patient Safety, 2, 2010, p141 - 152 Journal Article, 2010

Doyle, L. Keogh, B. & Lynch, A., Pharmacological Management of Alcohol Dependence Syndrome, Mental Health Practice, 14, (1), 2010, p14 - 19 Journal Article, 2010 DOI Handle TARA - Full Text

Lynch AM, Murphy KJ, Deighan BF, O'Reilly J-A, Gun'ko YK, Cowley TR, Gonzalez-Reyes RE, Lynch MA, The impact of glial activation in the aging brain , Aging and Disease, 1, (3), 2010, p264 - 278 Journal Article, 2010

Abuhusain, H.J. & Lynch A.M. , Modulation of claudin-5 and p-glycoprotein expression in the aged rat brain., Irish Journal of Medical Science, 179, (3), 2010, p95- Journal Article, 2010

Higgins A; Lynch A; Nash M, Antidepressants-Associated Sexual Dysfunction: Impact, Effects and Treatment , Drug, Healthcare and Patient Safety , 2, 2010, p141 - 150 Journal Article, 2010 TARA - Full Text DOI

Keogh, B., Lynch, A. & Doyle, L. , Pharmacological Management of Extra Pyramidal Side Effects, Nurse Prescribing, 2009 Journal Article, 2009

Loane DJ, Deighan BF, Clarke RM, Griffin RJ, Lynch AM, Lynch MA., Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain., Neurobiology of Aging, 30 , (6), 2009, p920 - 931 Journal Article, 2009 DOI

Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A, Lynch MA, Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro., Journal of Neurochemistry, 110, (5), 2009, p1547 - 1556 Journal Article, 2009 TARA - Full Text

Minogue AM, Lynch AM, Loane DJ, Herron CE, Lynch MA., Modulation of amyloid-beta-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid., Journal of Neurochemistry, 103, (3), 2007, p914 - 926 Journal Article, 2007

Lynch AM, Loane DJ, Minogue AM, Clarke RM, Kilroy D, Nally RE, Roche OJ, O'Connell F, Lynch MA., Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus., Neurobiology of Aging, 28, (6), 2007, p845 - 855 Journal Article, 2007

Barry CE, Nolan Y, Clarke RM, Lynch A, Lynch MA, Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus , Journal of Neurochemistry, 93, (1), 2005, p221 - 231 Journal Article, 2005 DOI URL

Lynch AM, Walsh C, Delaney A, Nolan Y, Campbell VA, Lynch MA., Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10 - a role for IL-1 beta?, Journal of Neurochemistry, 88, (3), 2004, p635 - 646 Journal Article, 2004

Nolan Y, Vereker E, Lynch AM, Lynch MA., Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus., Experimental Neurology, 184, (2), 2003, p794 - 804 Journal Article, 2003

Lynch AM, Moore M, Craig S, Lonergan PE, Martin DS, Lynch MA, Analysis of interleukin-1 beta-induced cell signaling activation in rat, Journal of Biological Chemistry, 278, (51), 2003, p51075 - 51084 Journal Article, 2003

Lynch AM, Lynch MA, The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation., European Journal of Neuroscience, 15, (11), 2002, p1779 - 1788 Journal Article, 2002 DOI URL

Kelly Á, Lynch A. Vereker E, Nolan Y, Queenan P, Whittaker E, O' Neill LAJ, Lynch MA. , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572 Journal Article, 2001 DOI TARA - Full Text

Vereker, Emily and O'Donnell, Eamonn and Lynch, Ailenn and Nolan, Yvonne and Lynch, Marina A., Evidence that interleukin-1beta and reactive oxygen species production play a pivotal role in stress-induced impairment of LTP in the rat dentate gyrus, European Journal of Neuroscience, 14, (11), 2001, p1809 - 1819 Journal Article, 2001 DOI URL

Research Expertise

Projects

  • Title
    • The impact of age and neuroinflammation on the blood-brain barrier and neurovascular unit
  • Summary
    • Our findings provide evidence of a structurally and functionally disrupted blood-brain barrier (BBB) with age. IL-1beta signalling mediates the tight junction protein disruption, as evidenced by the increased tight junction expression in aged IL-1R1-/- mice. This may be partially facilitated by its action on matrix metalloproteinases and via signalling through the ERK-MAPK pathway. Such age-related BBB disruption may facilitate the entry of potential neurotoxins into the brain, probably exacerbating neuronal damage with increasing age.
  • Date From
    • October 2009
  • Date To
    • September 2012
  • Title
    • RD-WIFI Infomation needs for families of children with rare diseases
  • Funding Agency
    • The Saoirse foundation
  • Date From
    • 01/03/2014
  • Date To
    • 30/09/14
  • Title
    • Rare Diseases Web-Information For Families in Ireland (RD-WIFI)
  • Funding Agency
    • Saoirse Foundation
  • Date From
    • March 2014
  • Date To
    • September 2014
  • Title
    • Liam's Lodge: A National Children's Care Centre for Children with Rare, Genetic and Life Limiting Conditions and A Children's Palliative Care Respite Service for Munster and the Mid-West.
  • Funding Agency
    • Saoirse Foundation
  • Date From
    • Dec 2014
  • Date To
    • April 2015
  • Title
    • Exploring the challenges experienced by people with muscular dystrophy living independently.
  • Funding Agency
    • Irish Research Council
  • Date From
    • April 2015
  • Date To
    • Dec 2015
  • Title
    • Rare diseases website - developing the parent2parent content of a rare disease website in Ireland.
  • Funding Agency
    • Irish Research Council
  • Date From
    • March 2015
  • Date To
    • Nov 2015
  • Title
    • Evaluating BUMBLEance - The Children's National Ambulance Service
  • Funding Agency
    • Saoirse Foundation
  • Date From
    • Jan 2016
  • Date To
    • April 2016
  • Title
    • Understanding the determinants of health and ill health in the aged: TILDA Project 2 :he predictors of physical activity change in the older adult
  • Summary
    • The predictors of physical activity change in the older adult. PhD Study
  • Funding Agency
    • Trinity College Dublin 1292 stipend award
  • Date From
    • 2015
  • Date To
    • 2018
  • Title
    • Enhancing Activity and Mobility in the Community for Healthy Ageing (MOVAGE-ACT)
  • Summary
    • The overall aim of the EIT funded study called 'MOVAGE-ACT' is to engage older people across Ireland and France in a series of health-oriented, community-based events and activities to promote active and healthy ageing.
  • Funding Agency
    • EIT Health
  • Date From
    • Jan 2019
  • Date To
    • Dec 2019

Keywords

Ageing, memory and other cognitive processes; Alzheimer's disease; Apoptosis; Astrocyte; Autoimmunity; BLOOD-BRAIN BARRIER; Cell and tissue maintenance, repair and ageing; Chronic inflamation; Consequences of ischemia or hypoxia, convulsive disorders; Cytokine; ENDOTHELIAL CELLS; Immune system; Microglia; Multiple Sclerosis; Nervous system, development, plasticiy and ageing; Neurochemistry and neuropharmacology; Neurodegeneration; Neuroendocrine Immunology; Neuropharmacology; Neurophysiology; Schizophrenia; Stress; TIGHT JUNCTION PERMEABILITY; Tight junction proteins

Recognition

Memberships

Physiological Society (Affiliate Member)

American Society for Neuroscience

British Neuroscience Association

Neuroscience Ireland