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Professor George Mellotte
Clinical Professor, Clinical Medicine

Biography

Professor George Mellotte is Consultant Nephrologist to St James's Hospital and to Tallaght University Hospital, Dublin since 1995. A graduate of National University of Ireland, Galway, he trained in nephrology in Dublin and London. He has a M.Sc. in Biochemistry from King's College, University of London. He has served as Clinical Lead Nephrologist for the Dublin Midlands Hospital Group prior to taking up his current role as National Clinical Lead for Renal Services. He is Clinical Associate Professor, School of Medicine in Trinity College Dublin.

His main research interest is in peritoneal dialysis and has published widely on this and other related topics. He has served on a several National and International clinical advisory boards and research groups. He was chair of the LOC for EuroPD 2017 conference that was held in Dublin. He has led clinical services on both Saint James's and Tallaght Hospital sites, overseeing a significant expansion of services, including home therapies and satellite dialysis centres.

Publications and Further Research Outputs

Peer-Reviewed Publications

O'Reilly VP, Wong L, Kennedy C, Elliot LA, O'Meachair S, Coughlan AM, O'Brien EC, Ryan MM, Sandoval D, Connolly E, Dekkema GJ, Lau J, Abdulahad WH, Sanders JS, Heeringa P, Buckley C, O'Brien C, Finn S, Cohen CD, Lindemeyer MT, Hickey FB, O'Hara PV, Feighery C, Moran SM, Mellotte G, Clarkson MR, Dorman AJ, Murray PT, Little MA., Urinary Soluble CD163 in Active Renal Vasculitis., Journal of the American Society of Nephrology, 27, (9), 2016, p2906 - 2916 Journal Article, 2016 URL DOI

Mellotte GJ, Ho CA, Morgan SH, Bending MR, Eisinger AJ, Peritoneal dialysis catheters: a comparison between percutaneous and conventional surgical placement techniques., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 8, (7), 1993, p626-30 Journal Article, 1993

Medani S, Hussein W, Shantier M, Flynn R, Wall C, Mellotte G, COMPARISON OF PERCUTANEOUS AND OPEN SURGICAL TECHNIQUES FOR FIRST-TIME PERITONEAL DIALYSIS CATHETER PLACEMENT IN THE UNBREACHED PERITONEUM., Peritoneal Dialysis International, (pdi.2013.00003), 2014 Journal Article, 2014 URL

Medani S, Shantier M, Hussein W, Wall C, Mellotte G, A comparative analysis of percutaneous and open surgical techniques for peritoneal catheter placement., Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 32, (6), 2012, p628-35 Journal Article, 2012

Foxall PJ, Mellotte GJ, Bending MR, Lindon JC, Nicholson JK, NMR spectroscopy as a novel approach to the monitoring of renal transplant function., Kidney international, 43, (1), 1993, p234-45 Journal Article, 1993

Davies SJ, Brown EA, Reigel W, Clutterbuck E, Heimbürger O, Diaz NV, Mellote GJ, Perez-Contreras J, Scanziani R, D'Auzac C, Kuypers D, Divino Filho JC, What is the link between poor ultrafiltration and increased mortality in anuric patients on automated peritoneal dialysis? Analysis of data from EAPOS., Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 26, (4), 2006, p458-65 Journal Article, 2006

Gunning H, Taylor G, Smyth A, Mellotte G, Fennell J, Murphy P, Lavin P, Wall C, An Approach to Optimise Therapeutic Vancomycin Dosage in a Haemodialysis Population., Irish Medical Journal, 109, (9), 2016, p465- Journal Article, 2016

Pate GE, Hogan MC, FitzSimon N, Mellotte GJ, A review of the epidemiology of leptospirosis in the Republic of Ireland., Irish medical journal, 93, (4), 2000, p114-7 Journal Article, 2000

Smyth A, McCann E, Redahan L, Lambert B, Mellotte GJ, Wall CA, Peritoneal dialysis in an ageing population: a 10-year experience., International urology and nephrology, 44, (1), 2012, p283 - 293 Journal Article, 2012

Mellotte GJ, Morgan SH, Smith SA, Bending MR, Eisinger AJ., Partial correction of dialysis associated anaemia does not reduce erythropoietin dose or incidence of side effects.,, Nephron, 64, (3), 1993, p465 - 467 Journal Article, 1993

Berzan, E and Mellotte, G and Silke, B, Prediction of hospital mortality by changes in the estimated glomerular filtration rate (eGFR), Irish medical journal, 108, (3), 2015, p87â€"89 Journal Article, 2015

Chin JL, O'Dowd S, Wan Md Adnan WA, Bennett K, O'Riordan D, Mellotte GJ, Silke B, Using the MDRD value as an outcome predictor in emergency medical admissions., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 26, (10), 2011, p3155-9 Journal Article, 2011

Corrigan C, Peterson L, McVeigh C, Lavin PJ, Mellotte GJ, Wall C, Baker Kerrigan A, Barnes L, O'Neill D, Moss H, The Perception of Art among Patients and Staff on a Renal Dialysis Unit, Ir Med J, 110, (9), 2017, pP633 Journal Article, 2017 URL

McCann M, Fitzpatrick F, Mellotte G, Clarke M. , Is 2% chlorhexidine gluconate in 70% isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: A pilot multicenter randomized trial (ISRCTN2657745)? , American Journal of Infection Control, 44, (8), 2016, p948 - 949 Journal Article, 2016 TARA - Full Text

Martin A, Mellotte G, O'Neill D, Chronic kidney disease in the elderly; a silent epidemic., Irish medical journal, 98, (2), 2005, p46-7 Journal Article, 2005

Bending, M, Mellotte, G, Hashmi, C, Coles, GA, Morgan, JD, Ashman, R, Schurgers, ML, Gordis, BZ, DHoore, MM, Faller, B, Genestier, S, Grawey, I, Slingeneyer, A, Laroche, B, Ville, JL, Winney, RJ, Plant, WD, Miles, RS, Scouse, P, Williams, P, Moncrieff, N, Brown, C, Norman, P, Nichols, N, Rennes, JG, Holmes, CJ, Hudson, I, Horton, D, Nasal mupirocin prevents Staphylococcus aureus exit-site infection during peritoneal dialysis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 7, 1996 Journal Article, 1996

Frazão JM, Messa P, Mellotte GJ, Geiger H, Hagen EC, Quarles LD, Kerr PG, Baños A, Dehmel B, Urena P, Cinacalcet reduces plasma intact parathyroid hormone, serum phosphate and calcium levels in patients with secondary hyperparathyroidism irrespective of its severity., Clinical nephrology, 76, (3), 2011, p233-43 Journal Article, 2011

MELLOTTE, GJ, Gaffney EF, Keogh JA., Thrombotic microangiopathy and renal failure as the initial manifestation of Hodgkin's disease., 1993, p1993;8(1):94-5 Journal Article, 1993

Douds, AC, Mellotte, GJ, Morgan, SH, Fatal Merkel-cell tumour (cutaneous neuroendocrine carcinoma) complicating renal transplantation, NEPHROLOGY DIALYSIS TRANSPLANTATION, 10, 1995 Journal Article, 1995

Fanning DM, Sabah M, Conlon PJ, Mellotte GJ, Donovan MG, Little DM, An unusual case of cancer of the urachal remnant following repair of bladder exstrophy., Irish journal of medical science, 180, (4), 2011, p913-5 Journal Article, 2011

EUSTACE, J, LAPAROSCOPIC-AIDED DIAGNOSIS OF RECURRENT PERITONITIS IN A PATIENT ON CAPD, NEPHROLOGY DIALYSIS TRANSPLANTATION, 11, 1996, p2338 - 2339 Journal Article, 1996

Eustace JA, Mellotte GJ, Keogn JA., Treatment of post-transplant erythrocytosis by angiotensin II type I receptor antagonists., 1996, p1993;8(1):94-5 Journal Article, 1996

Brady, HR, Harrington, JT, Garrett, P, Donohoe, J, O'Meara, Y, Keogh, BA, Fitzpatrick, JM, Sheahan K, Dorman, A, Gaffney, E, Murnaghan, D, Cottell , DC, Mellotte GJ ,Muldowney F, FIBRILLARY GLOMERULOPATHY, 1998, p1421 - 1429 Journal Article, 1998

Maxwell, AP, Harrington, JT, Conlon, P, Harty, J, Mellotte, G, Brown, H, Kalra, P, Abraham, K, Muldowney, F, Plant, L, Cronin, C, Brady, H, Donohoe, J, Reeden, D, O'Meara, Y, Fogarty, D, Keogh, B, Garrett, P, Novel erythropoiesis-stimulating protein in the management of the anemia of chronic renal failure, KIDNEY INTERNATIONAL, 62, 2002 Journal Article, 2002

HODGSON, A, RYAN, T, MORIARTY, J, MELLOTTE, G, MURPHY, C, SMITH, OP, PLASMA EXCHANGE AS A SOURCE OF PROTEIN C FOR ACUTE ONSET PROTEIN C PATHWAY FAILURE, BRITISH JOURNAL OF HAEMATOLOGY, 116, 2002, p905 - 908 Journal Article, 2002

Smyth A, Redahan L, Wall C, Mellotte GJ, Porphyria or not porphyria - that is the question..., BMJ case reports, 2010, 2010 Journal Article, 2010

Smyth A, Redahan L, Rahman T, Wall C, Mellotte GJ, An atypical pleural effusion., BMJ case reports, 2010, 2010 Journal Article, 2010

mutwali A, Muhammad K, Mellotte GJ. Reddan D , Do Calcimimetics Have a Role in Management?, Arab Journal of Nephrology and Transplantation, 3, (1), 2010, p45 - 48 Journal Article, 2010

WALL, CH, MELLOTTE, GJM, KEOGH, JAB, LOW-GRADE LYMPHOMA IN A CADAVERIC RENAL TRANSPLANT DONOR FOLLOWING ORGAN TRANSPLANTATION: RECIPIENT MANAGEMENT AND OUTCOME, NEPHROLOGY DIALYSIS TRANSPLANTATION, 15, 2000, p1069 - 1071 Journal Article, 2000

Davies SJ, Brown EA, Frandsen NE et al, Longitudinal membrane function in functionally anuric patients treated with APD: data from EAPOS on the effects of glucose and icodextrin prescription, Kidney Int., 67, (4), 2005, p1609 - 1615 Journal Article, 2005

WALL, CA, POLYMORPHISMS OF THE TUMOUR NECROSIS FACTOR-ALPHA GENE IN IGA NEPHROPATHY., unknown, 2002, 13, ISI Web of Science, 2002, pp132A - 132A Meeting Abstract, 2002

Flynn A, de Bhailis A, Tobin AM, Mellotte G, Connolly M, Pancreatitis associated with calciphylaxis successfully treated with sodium thiosulfate., JAAD case reports, 2018 Journal Article, 2018

BROWN, EA, DAVIES, SJ, HEIMBURGER, O, MEEUS, F, MELLOTTE, G, ROSMAN, J, RUTHERFORD, P, VAN BREE, M, EAPOS INVESTIGATORS, ADEQUACY TARGETS CAN BE MET IN ANURIC PATIENTS BY AUTOMATED PERITONEAL DIALYSIS: BASELINE DATA FROM EAPOS, PERITONEAL DIALYSIS INTERNATIONAL, 21, 2002, pS133 - S137 Journal Article, 2002

WALL, CAM, HYPERCALCAEMIA AND ACUTE INTERSTITIAL NEPHRITIS ASSOCIATED WITH OMEPRAZOLE THERAPY, NEPHROLOGY DIALYSIS TRANSPLANTATION, 15, 2000, p1450 - 1452 Journal Article, 2000

Riardon T, Kavanagh P, Mellotte GJ, et al, HEMOLYTIC UREMIC SYNDROME WITH SHIGELLA, Irish Medical Journal , 1990, p72 - 73 Journal Article, 1990

Hossein-Nia M, Mellotte GJ, Foxall P, Bending MR, Holt DW, Urinary protein excretion and the diagnosis of graft rejection and renal dysfunction in renal transplant patients. , Human Toxicology, , 12, 1993, p407 - 409 Journal Article, 1993

Flynn, Aoibheann and de Bhailis, Aine and Tobin, Ann-Marie and Mellotte, George and Connolly, Maureen, Caliphylaxis causes recurrent pancreatitus, JAAD Case Reports, 5, (2), 2019, p134 Journal Article, 2019 DOI

Hogan MC, Pate G, McConkey SJ, O'Flanagan D, Mongan C, Mellotte GJ. , Leptospirosis in the Republic of Ireland: 1985 to 1996. , Communicable Disease Report Public Health . , 14, (7), 1997, p185 - 189 Journal Article, 1997

Brown EA, Davies SJ, Rutherford P, et al for the EAPOS Group. , Survival of functionally anuric patients on automated peritoneal dialysis: the European APD Outcome Study, Journal American Society of Nephrology , 14, (11), 2003, p2948 - 2957 Journal Article, 2003

Pate G, FitzSimon N, Mellotte GJ, Leptospirosis in the South-Eastern Health Board region of the Republic of Ireland: 1990 to 1996. , Communicable Disease Report Public Health . , 2, (3), 1999, p217 - 218 Journal Article, 1999

Parfrey PS, Foley RN, Wittreich BH, Sullivan DJ, Zagari MJ, Frei D for the Canadian European Study Group,, Double-Blind Comparison of Full and Partial Anaemia Correction in Incident Haemodialysis Patients without Symptomatic Heart Disease , Journal American Society of Nephrology , 16, 2005, p2180 - 2189 Journal Article, 2005

Harris KP, Wheeler DC, Chong CC et al, A placebo-controlled trial examining atorvastatin in dyslipidemic patients undergoing CAPD, Kidney International, 61, (4), 2002, p1469 - 1474 Journal Article, 2002

Bolodeoku J, Mellotte GJ, Acute serum lipid changes in a renal transplant recipient on intravenous cyclosporin upon administration of an intravenous lipid solution, Postgraduate Medicine , 70, (829), 1994, p849 - 850 Journal Article, 1994

Messa, Piergiorgio and Macário, Fernando and Yaqoob, Magdi and Bouman, Koen and Braun, Johann and von Albertini, Beat and Brink, Hans and Maduell, Francisco and Graf, Helmut and Frazão, João M and Bos, Willem Jan and Torregrosa, Vicente and Saha, Heikki and Reichel, Helmut and Wilkie, Martin and Zani, Valter J and Molemans, Bart and Carter, Dave and Locatelli, Francesco, The OPTIMA study: assessing a new cinacalcet (Sensipar/Mimpara) treatment algorithm for secondary hyperparathyroidism, Clinical journal of the American Society of Nephrology : CJASN, 3, (1), 2008, p36â€"45 Journal Article, 2008 DOI

Bourke JF, Mellotte GJ, Young M, Keogh JAB, A comparative analysis of skin neoplasia in renal transplant patients on Cyclosporin or Azathioprine., Irish Journal of Medical Science , 161(4) 116-7, 1992 Journal Article, 1992

Foley RB, Curtis BM, Parfrey PS on behalf of Canadian European Study Group., Erythropoietin Therapy, Hemoglobin Targets, and Quality of Life in Healthy Hemodialysis Patients: A Randomized Trial,, Clinical Journal American Society of Nephrology , (4), 2009, p726 - 733 Journal Article, 2009

McCann, M., Clarke, M., Mellotte, G., Plant, L. & Fitzpatrick, F. , Vascular access and infection prevention and control: a national survey of routine practices in Irish haemodialysis units, Clinical Kidney Journal , 6, (2), 2013, p176 - 182 Journal Article, 2013 DOI TARA - Full Text

Foley, Robert N and Curtis, Bryan M and Randell, Edward W and Parfrey, Patrick S, Left ventricular hypertrophy in new hemodialysis patients without symptomatic cardiac disease, Clinical journal of the American Society of Nephrology : CJASN, 5, (5), 2010, p805â€"813 Journal Article, 2010 DOI

Foley, Robert N and Curtis, Bryan M and Parfrey, Patrick S, Hemoglobin targets and blood transfusions in hemodialysis patients without symptomatic cardiac disease receiving erythropoietin therapy, Clinical journal of the American Society of Nephrology : CJASN, 3, (6), 2008, p1669â€"1675 Journal Article, 2008 DOI

Mellotte, GJ and Eastwood, JB, Pathognomonic sign of triangular lunulae in the nail-patella syndrome, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 10, (2), 1995, p300â€"301 Journal Article, 1995

BERZAN, E., KECLER-PIETRZYK, A., KAVANAGH, J., LEONARD, N., WALL, C., MELLOTTE, G.., Right Atrial Pseudomyxoma in a Haemodialysis Patient With a Permanent Dialysis Catheter. , Journal of Medical Cases, 4, 2012, http://dx.doi.org/10.4021/jmc Journal Article, 2012

Bernadette Brady, Lynn Redahan, Claire L. Donohoe, George J. Mellotte, Catherine Wall & Stephen Higgins , Renal patients at end of life: A 5-year retrospective review, , Progress in Palliative Care,, 25, (5), 2017, p224 - 229 Journal Article, 2017

Non-Peer-Reviewed Publications

48. Connell J, Casserly L, Conlon P, Crowley B, Donlon S, Mellotte GJ, Thornton T. , 'Blood-Borne Viruses in the Haemodialysis, CAPD and Renal Transplantation Setting 2013', www.ndsc.ie/hpsc/A-Z/Hepatitis, HSE, 2013, - Protocol or guideline, 2013 URL

Mellotte GJ, Nephrology in the ICU. , Registrars review in Nephrology, (4), 1993, p13 - 15 Journal Article, 1993

Allcutt D, Bedford D, Bennett D, Byrne J, Carroll P, Cummins G, Cusack D, Delargy I, Dolan M, Farrell B, Faughnan C, Fearon P, Finnerty D, Fitzpatrick P, Flannery W, Gormley M, Guéret P, Joyce Cooney J, Keane L, Keelan E, Lane G, Logan P, McCabe P, McMahon S, McNicholas W, Mellotte G, Mullan R, Norman D, O'Brien M, O'Callaghan S, Patterson I, Roberts G, Robinson D, Sludds K, Stapleton T, Treacy G, Wallace E, Walsh K, Whelan D, Williams D, O'Neill D. , 'Medical Fitness to Drive Guidelines Report, ', www.rsa.ie, Road safety Authority, 2015, 1 - 98 Protocol or guideline, 2015

Glynn LG, Reddan D, Hayes L, Stack A, Casserly L, Mellotte GJ., New guidelines for the management of chronic kidney disease in primary care, Irish Pharmacist , 8, (11), 2008, p34 - 37 Journal Article, 2008

Mellotte, Epoetin - An Important Advance, Drugs And Therapeutics Bulletin, 30, (8), 1992, p29 - 32 Journal Article, 1992

Casey, MC, Walsh JB, Mellotte GJ, et al, Joint Specialist Care for Elderly Renal Transplants, British Medical Journal, (9), 2004 Journal Article, 2004

Research Expertise

Keywords

AUTOMATED PERITONEAL DIALYSIS; GLOMERULONEPHRITIS; NEPHROTIC SYNDROME; PLASMA EXCHANGE; RENAL-TRANSPLANTATION

Recognition

Representations

National Clinical Lead - Nephrology National Clinical Director: National Renal Office 1/11/18

Memberships

Irish Nephrology Society (President 2006-10) 1997

ERA-EDTA (European Renal Association- Dialysis Transplant association) 1993

International Society of Peritoneal Dialysis 2004